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Article

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR-Based Genetic Analyses and Experimental Models.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2026

Nie Zuqing, Xu Xinyi, Chen Junhao, Chen Huiling, Li Meng, Zhang Yang, Li Zhiwei, Shen Chen, Wen Jie, Cao Xia

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood. We employed Mendelian Randomization (MR) to...

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PMID: 40927973
DOI: 10.1002/ajmg.b.33061

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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