Article
Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2018
Oldoni Federico, van Capelleveen Julian C, Dalila Nawar, Wolters Justina C, Heeren Joerg, Sinke Richard J, Hui David Y, Dallinga-Thie Geesje M, Frikke-Schmidt Ruth, Hovingh Kees G, van de Sluis Bart, Tybjærg-Hansen Anne, Kuivenhoven Jan Albert
Abstract excerpt
OBJECTIVE: Studies into the role of LRP1 (low-density lipoprotein receptor-related protein 1) in human lipid metabolism are scarce. Although it is known that a common variant in LRP1 (rs116133520) is significantly associated with HDL-C (high-density lipoprotein cholesterol), the mechanism underlying this observation is unclear. In this study, we set out to study the functional effects of 2 rare LRP1 variants...
Topics
- ATP Binding Cassette Transporter 1
- Apolipoprotein A-I
- Cell Line, Tumor
- Cell Membrane
- Cholesterol, HDL