Article
Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments.
FEBS letters - 7 May 1999
Goedert M, Jakes R, Crowther R A
Abstract excerpt
Missense mutations and intronic mutations in the gene for microtubule-associated protein tau cause frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). Most missense mutations have as likely primary effect a reduced ability of tau to interact with microtubules. We report here an additional effect of several missense mutations, namely the stimulation of heparin-induced filament assembly of...
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