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Article

Structural and microtubule binding properties of tau mutants of frontotemporal dementias.

Biochemistry - 13 Mar 2007

Fischer Daniela, Mukrasch Marco D, von Bergen Martin, Klos-Witkowska Aleksandra, Biernat Jacek, Griesinger Christian, Mandelkow Eckhard, Zweckstetter Markus

Abstract excerpt

Several mutations in the gene encoding the microtubule-associated protein tau are responsible for the formation of neurofibrillary inclusions in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Here we present the high-resolution characterization of the conformational properties of two FTDP-17 mutants of the four-repeat domain of tau, P301L and DeltaK280, and their properties for...

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Identifiers

PMID: 17297915
DOI: 10.1021/bi061318s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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