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Article

Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments.

Brain research - 8 May 2004

Gómez-Ramos Alberto, Abad Xabier, López Fanarraga Mónica, Bhat Ratan, Zabala Juan Carlos, Avila Jesús

Abstract excerpt

Tau is the main component of the paired helical filaments (PHFs), aberrant structures that develop in the brain of Alzheimer's disease (AD) patients and other tauopathies like frontotemporal dementia and parkinsonism associated to chromosome 17 (FTDP-17). Previous work has shown that tau overexpression in Sf9 insect cells results in the formation of long cytoplasmatic extensions as a consequence of microtubule...

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Identifiers

PMID: 15064135
DOI: 10.1016/j.brainres.2004.01.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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