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Article

Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress.

Molecular biology of the cell - 1 Jun 2018

Sundaram Arunkumar, Appathurai Suhila, Plumb Rachel, Mariappan Malaiyalam

Abstract excerpt

The endoplasmic reticulum (ER) localized unfolded protein response (UPR) sensors, IRE1α, PERK, and ATF6α, are activated by the accumulation of misfolded proteins in the ER. It is unclear how the endogenous UPR sensors are regulated by both ER stress and the ER luminal chaperone BiP, which is a negative regulator of UPR sensors. Here we simultaneously examined the changes in the endogenous complexes of UPR sensors...

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Identifiers

PMID: 29851562
DOI: 10.1091/mbc.E17-10-0594
PMCID: PMC5994896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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