Article
IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma.
Scientific reports - 5 Nov 2015
Kickingereder Philipp, Sahm Felix, Radbruch Alexander, Wick Wolfgang, Heiland Sabine, Deimling Andreas von, Bendszus Martin, Wiestler Benedikt
Abstract excerpt
The recent identification of IDH mutations in gliomas and several other cancers suggests that this pathway is involved in oncogenesis; however effector functions are complex and yet incompletely understood. To study the regulatory effects of IDH on hypoxia-inducible-factor 1-alpha (HIF1A), a driving force in hypoxia-initiated angiogenesis, we analyzed mRNA expression profiles of 288 glioma patients and show...
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