Article
The MR-Base platform supports systematic causal inference across the human phenome.
eLife - 30 May 2018
Hemani Gibran, Zheng Jie, Elsworth Benjamin, Wade Kaitlin H, Haberland Valeriia, Baird Denis, Laurin Charles, Burgess Stephen, Bowden Jack, Langdon Ryan, Tan Vanessa Y, Yarmolinsky James, Shihab Hashem A, Timpson Nicholas J, Evans David M, Relton Caroline, Martin Richard M, Davey Smith George, Gaunt Tom R, Haycock Philip C
Abstract excerpt
Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base...
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