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Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa

24 May 2018

Abstract excerpt

ABSTRACT Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn 3 -like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in...

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PMID: 29844041
DOI: 10.1128/aac.00679-18

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