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Comparative genomics of colistin-nonsusceptible multidrug-resistant Pseudomonas aeruginosa reveals emerging lineages in Thailand.

Scientific reports - 21 Jan 2026

Wankaew Natnicha, Arigul Tantip, Kruasuwan Worarat, Jenjaroenpun Piroon, Wongsurawat Thidathip, E-Kobon Teerasak, Unahalekhaka Aekkawat, Laosena Phatcharin, Premsuriya Jiraphan

Abstract excerpt

Pseudomonas aeruginosa is a leading cause of multidrug-resistant (MDR) infections, for which the polymyxin antibiotic colistin has been a treatment of last resort. The emergence of colistin-nonsusceptible strains thus poses a serious therapeutic challenge. In this study, we performed whole-genome sequencing and comparative genomic analysis of 29 colistin-nonsusceptible MDR P. aeruginosa clinical isolates...

Topics

Colistin
Thailand
Pseudomonas aeruginosa
Drug Resistance, Multiple, Bacterial
Anti-Bacterial Agents
Phylogeny
Genomics
Genome, Bacterial
Humans
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Whole Genome Sequencing

Pseudomonas Infections

Polymorphism, Single Nucleotide

beta-Lactamases

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Open in PubMed Open full text

Identifiers

PMID: 41559330
DOI: 10.1038/s41598-026-35520-7
PMCID: PMC12901977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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