New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5.

doi:10.1128/AAC.01757-17

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Article

New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5.

Antimicrobial agents and chemotherapy - 1 Dec 2017

Liu Lu, Feng Yu, Zhang Xiaoxia, McNally Alan, Zong Zhiyong

Abstract excerpt

A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3, and a carbapenemase gene, blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a TnAs3-like transposon on a self-transmissible IncP plasmid in...

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PMID: 28971871
DOI: 10.1128/AAC.01757-17
PMCID: PMC5700326

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