Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.

Nucleic acids research - 1 Jan 2005

Mulder Klaas W, Winkler G Sebastiaan, Timmers H Th Marc

Abstract excerpt

Genetic experiments have indicated a role for the Ccr4-Not complex in the response to hydroxyurea (HU) induced replication stress and ionizing radiation in yeast. This response includes transcriptional induction of the four genes constituting the ribonucleotide reductase (RNR) enzymatic complex, RNR1-4 and degradation of its inhibitor, Sml1p. The Ccr4-Not complex has originally been described as a negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Replication
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyurea

Share to Protein Subunits

Share to Ribonucleases

Share to Ribonucleotide Reductases

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 16275785
DOI: 10.1093/nar/gki938
PMCID: PMC1278945

Genes

CCR4
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.PMID 16275785Read ↗

The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.Semantic proximity Read ↗

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.Semantic proximity Read ↗

Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication.Semantic proximity Read ↗

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.Semantic proximity Read ↗

DNA damage and cell cycle regulation of ribonucleotide reductase.Semantic proximity Read ↗

A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

CCR4-NOT complex nuclease Caf1 is a novel shuttle factor involved in the degradation of ubiquitin-modified proteins by 26S proteasomeSemantic proximity Read ↗

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.Semantic proximity Read ↗

The Ccr4-not complex regulates Skn7 through Srb10 kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.