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Article

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

Journal of molecular biology - 12 Mar 2004

Winkler G Sebastiaan, Albert Thomas K, Dominguez Cyril, Legtenberg Yvonne I A, Boelens Rolf, Timmers H Th Marc

Abstract excerpt

The human CCR4-NOT complex is a global regulator of RNA polymerase II transcription. Recently, we showed that the RING domain CNOT4 subunit contains intrinsic ubiquitin-protein ligase (E3) activity. Here we show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective. To understand the basis for this interaction, we identified several basic residues of UbcH5B...

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Source

Identifiers

PMID: 15001359
DOI: 10.1016/j.jmb.2004.01.031

Genes

CNOT4
CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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