Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.

Genetics - 1 May 2007

Mulder Klaas W, Inagaki Akiko, Cameroni Elisabetta, Mousson Florence, Winkler G Sebastiaan, De Virgilio Claudio, Collart Martine A, Timmers H Th Marc

Abstract excerpt

The Ccr4-Not complex consists of nine subunits and acts as a regulator of mRNA biogenesis in Saccharomyces cerevisiae. The human ortholog of yeast NOT4, CNOT4, displays UbcH5B-dependent ubiquitin-protein ligase (E3 ligase) activity in a reconstituted in vitro system. However, an in vivo role for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heat-Shock Response
Share to Hydroxyurea
Share to Hygromycin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Proteins

Share to Ribonucleases

Share to Ubiquitin

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 17513889
DOI: 10.1534/genetics.106.060640
PMCID: PMC1893070

Genes

CNOT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17513889-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.PMID 17513889Read ↗

The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.Semantic proximity Read ↗

The Ccr4-not complex regulates Skn7 through Srb10 kinase.Semantic proximity Read ↗

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

The inactivation of KlNOT4, a Kluyveromyces lactis gene encoding a component of the CCR4-NOT complex, reveals new regulatory functions.Semantic proximity Read ↗

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.Semantic proximity Read ↗

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.Semantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

CCR4-NOT complex nuclease Caf1 is a novel shuttle factor involved in the degradation of ubiquitin-modified proteins by 26S proteasomeSemantic proximity Read ↗

Human CCR4-NOT globally regulates gene expression and is a novel silencer of retrotransposon activationSemantic proximity Read ↗

The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.Semantic proximity Read ↗

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.Semantic proximity Read ↗

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.