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Article

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

Scientific reports - 25 May 2018

Vogt Miriam A, Ehsaei Zahra, Knuckles Philip, Higginbottom Adrian, Helmbrecht Michaela S, Kunath Tilo, Eggan Kevin, Williams Luis A, Shaw Pamela J, Wurst Wolfgang, Floss Thomas, Huber Andrea B, Taylor Verdon

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a key player in neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Accumulation of TDP-43 is associated with neuronal death in the brain. How increased and disease-causing mutant forms of TDP-43 induce cell death remains unclear. Here we addressed the role of TDP-43 during neural development and show that...

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Identifiers

PMID: 29802307
DOI: 10.1038/s41598-018-26397-2
PMCID: PMC5970242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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