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Article

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.

Nature reviews. Neuroscience - 30 Nov 2011

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q

Abstract excerpt

RNA-binding proteins, and in particular TAR DNA-binding protein 43 (TDP43), are central to the pathogenesis of motor neuron diseases and related neurodegenerative disorders. Studies on human tissue have implicated several possible mechanisms of disease and experimental studies are now attempting to determine whether TDP43-mediated neurodegeneration results from a gain or a loss of function of the protein. In...

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Identifiers

PMID: 22127299
DOI: 10.1038/nrn3121
PMCID: PMC3285250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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