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Article

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

PloS one - 1 Jan 2013

Zhang Zhijun, Almeida Sandra, Lu Yubing, Nishimura Agnes L, Peng Lingtao, Sun Danqiong, Wu Bei, Karydas Anna M, Tartaglia Maria C, Fong Jamie C, Miller Bruce L, Farese Robert V, Moore Melissa J, Shaw Christopher E, Gao Fen-Biao

Abstract excerpt

Transactive response DNA-binding protein 43 (TDP-43) is a major pathological protein in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many disease-associated mutations in TDP-43, and several cellular and animal models with ectopic overexpression of mutant TDP-43 have been established. Here we sought to study altered molecular events in FTD and ALS by using induced pluripotent...

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Identifiers

PMID: 24143176
DOI: 10.1371/journal.pone.0076055
PMCID: PMC3797144

Genes

TARDBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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