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Article

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.

Nature communications - 29 Jan 2015

Li Quan, Yokoshi Moe, Okada Hitomi, Kawahara Yukio

Abstract excerpt

TAR DNA-binding protein of 43 kDa (TDP-43) and its C-terminal fragment of 25 kDa (CTF25) play critical roles in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Although the overexpression of TDP-43 in cultured cells and animals results in the production of CTF25, the cleavage site that generates CTF25 and biological significance of the cleavage remain undetermined. Here we identify Asp174 as...

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PMID: 25630387
DOI: 10.1038/ncomms7183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.PMID 25630387Read ↗

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