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Article

Motor neuron differentiation of iPSCs obtained from peripheral blood of a mutant TARDBP ALS patient.

Stem cell research - 1 Jul 2018

Bossolasco Patrizia, Sassone Francesca, Gumina Valentina, Peverelli Silvia, Garzo Maria, Silani Vincenzo

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, mainly affecting the motor neurons (MNs) and without effective therapy. Drug screening is hampered by the lack of satisfactory experimental and pre-clinical models. Induced pluripotent stem cells (iPSCs) could help to define disease mechanisms and therapeutic strategies as they could be differentiated into MNs, otherwise inaccessible from...

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Source

Identifiers

PMID: 29800782
DOI: 10.1016/j.scr.2018.05.009

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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