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Article

Generation of an induced pluripotent stem cell line (CSS012-A (7672)) carrying the p.G376D heterozygous mutation in the TARDBP protein.

Stem cell research - 1 May 2021

D'Anzi Angela, Altieri Filomena, Perciballi Elisa, Ferrari Daniela, Torres Barbara, Bernardini Laura, Lattante Serena, Sabatelli Mario, Vescovi Angelo Luigi, Rosati Jessica

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative condition with phenotypic and genetic heterogeneity. It is characterized by the selective vulnerability and the progressive loss of the neural population. Here, an induced pluripotent stem cell (iPSC) line was generated from dermal fibroblasts of an individual carrying the p.G376D mutation in the TDP-43 protein. Fibroblasts were reprogrammed...

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Identifiers

PMID: 34087986
DOI: 10.1016/j.scr.2021.102356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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