Article
Generation of an induced pluripotent stem cell line (UCSCi002-A) from a patient with a variant in TARDBP gene associated with familial amyotrophic lateral sclerosis and frontotemporal dementia.
Stem cell research - 1 Jul 2022
Martello Francesco, Lattante Serena, Doronzio Paolo Niccolò, Conte Amelia, Bisogni Giulia, Orteschi Daniela, Luigetti Marco, Marrucci Maria Alessandra, Zollino Marcella, Sabatelli Mario, Marangi Giuseppe
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively affects motor neurons. In 20% of cases, ALS appears in comorbidity with frontotemporal dementia (FTD). We generated patient-derived-induced Pluripotent Stem Cells (iPSCs), from an ALS/FTD patient. The patient had a familial form of the disease and a missense variant in TARDBP gene. We used an established protocol based on...
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