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Article

Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice.

PloS one - 1 Jan 2013

Yao Xiao-Li, Ye Cheng-Hui, Liu Qiang, Wan Jian-bo, Zhen Jun, Xiang Andy Peng, Li Wei-Qiang, Wang Yitao, Su Huangxing, Lu Xi-Lin

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder mainly affecting motor neurons. Mutations in superoxide dismutase-1 (SOD-1) account for about 20% of familial ALS patients. A robust supply of motoneurons carrying the mutated gene would help understand the causes of motoneuron death and develop new therapeutics for the disease. Here, we established induced pluripotent stem (iPS) cell lines from...

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Identifiers

PMID: 23724084
DOI: 10.1371/journal.pone.0064720
PMCID: PMC3665598

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