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Article

Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.

European journal of human genetics : EJHG - 1 Aug 2021

Gervais Olivier, Ueno Kazuko, Kawai Yosuke, Hitomi Yuki, Aiba Yoshihiro, Ueta Mayumi, Nakamura Minoru, Tokunaga Katsushi, Nagasaki Masao

Abstract excerpt

While the advent of GWAS more than a decade ago has ushered in remarkable advances in our understanding of complex traits, the limitations of single-SNP analysis have also led to the development of several other approaches. Simulation studies have shown that the regional heritability mapping (RHM) method, which makes use of multiple adjacent SNPs jointly to estimate the genetic effect of a given region of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33833419
DOI: 10.1038/s41431-021-00854-5
PMCID: PMC8385030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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