N-Linked Glycosylation Is Not Essential for Sodium Taurocholate Cotransporting Polypeptide To Mediate Hepatitis B Virus Infection In Vitro.

doi:10.1128/JVI.00732-18

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Article

N-Linked Glycosylation Is Not Essential for Sodium Taurocholate Cotransporting Polypeptide To Mediate Hepatitis B Virus Infection In Vitro.

Journal of virology - 1 Aug 2018

Lee Jiwon, Zong Li, Krotow Alexander, Qin Yanli, Jia Lucy, Zhang Jiming, Tong Shuping, Li Jisu

Abstract excerpt

Sodium taurocholate cotransporting polypeptide (NTCP) has been identified as a hepatitis B virus (HBV) receptor, and its overexpression in HepG2 cell lines leads to efficient secretion of hepatitis B e antigen (HBeAg) following challenge with a large dose of cell culture-derived HBV (cHBV) particles. However, NTCP-reconstituted HepG2 cells are inefficiently infected by patient serum-derived HBV (sHBV) and release...

Topics

Glycosylation
Hep G2 Cells
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Mutation
Organic Anion Transporters, Sodium-Dependent
Symporters
Viral Proteins

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Identifiers

PMID: 29793953
DOI: 10.1128/JVI.00732-18
PMCID: PMC6052319

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