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Article

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

5 Apr 2019

Abstract excerpt

Significance For achieving efficient entry into host cells, viruses utilize multiple host factors for mediating the stepwise entry process. Sole expression of sodium taurocholate cotransporting polypeptide (NTCP), a cellular receptor for hepatitis B virus (HBV), is not sufficient for the efficient viral internalization into hepatocytes. Here, we identify epidermal growth factor receptor (EGFR) as a host factor...

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PMID: 30952782
DOI: 10.1073/pnas.1811064116

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