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Article

Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells

2 Aug 2012

Abstract excerpt

Liver infection with hepatitis B virus (HBV), a DNA virus of the Hepadnaviridae family, leads to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps of the viral life cycle are largely obscure and the host cell plasma membrane receptors are not known. HepaRG is the only proliferating cell line supporting HBV infection in vitro, following specific differentiation, allowing for...

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PMID: 22857383
DOI: 10.1186/1477-5956-10-47

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