Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells.

Biochemistry - 20 Feb 2018

Saad Ahmad, Liet Benjamin, Joucla Gilles, Santarelli Xavier, Charpentier Justine, Claverol Stéphane, Grosset Christophe F, Trézéguet Véronique

Abstract excerpt

Glypican 3 (GPC3) is a complex heparan sulfate proteoglycan associated with the outer surface of the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is also N-glycosylated and processed by a furin-like convertase. GPC3 has numerous biological functions. Although GPC3 is undetectable in normal liver tissue, it is abnormally and highly overexpressed in hepatocellular carcinoma (HCC)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosaminoglycans

Share to Glypicans

Share to Hep G2 Cells

Share to Liver Neoplasms

Share to Protein Processing, Post-Translational

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 29345911
DOI: 10.1021/acs.biochem.7b01208

Genes

GPC3
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells.PMID 29345911Read ↗

Biology and function of glypican-3 as a candidate for early cancerous transformation of hepatocytes in hepatocellular carcinomaSemantic proximity Read ↗

Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver CarcinogenesisSemantic proximity Read ↗

Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo.Semantic proximity Read ↗

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.Semantic proximity Read ↗

Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cellsSemantic proximity Read ↗

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinomaSemantic proximity Read ↗

New tumor suppressor microRNAs target glypican-3 in human liver cancerSemantic proximity Read ↗

Engineered E. coli OMVs Carrying the Membrane-Binding hGC33 Fragment Precisely Target Liver Cancer and Effectively Treat TumorSemantic proximity Read ↗

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancerSemantic proximity Read ↗

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathwaySemantic proximity Read ↗

Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathwaySemantic proximity Read ↗

Exploring Glypican-3 Targeted CAR-NK Treatment and Potential Therapy Resistance in Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.