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Article

A robust cell culture system supporting the complete life cycle of hepatitis B virus

24 Nov 2017

Abstract excerpt

The discovery of sodium taurocholate cotransporting polypeptide (NTCP) as the hepatitis B virus (HBV) receptor enabled researchers to create hepatoma cell lines susceptible to HBV infection. Infection in current systems, however, is inefficient and virus fails to spread. Infection efficiency is enhanced by treating cells with polyethylene glycol 8000 (PEG) during infection. However, this alone does not promote...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29192196
DOI: 10.1038/s41598-017-16882-5

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