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Article

Does arterial hypertension influence the onset of Huntington's disease?

PloS one - 1 Jan 2018

Valcárcel-Ocete Leire, Fullaondo Asier, Alkorta-Aranburu Gorka, García-Barcina María, Roos Raymund A C, Hjermind Lena E, Saft Carsten, Frontali Marina, Reilmann Ralf, Rickards Hugh, Zubiaga Ana M, Aguirre Ana

Abstract excerpt

Huntington's disease (HD) age of onset (AO) is mainly determined by the length of the CAG repeat expansion in the huntingtin gene. The remaining AO variability has been attributed to other little-known factors. A factor that has been associated with other neurodegenerative diseases is arterial hypertension (AHT). The aim of this study is to evaluate the contribution of AHT to the AO of HD. We used data from a...

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PMID: 29791508
DOI: 10.1371/journal.pone.0197975
PMCID: PMC5965871

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