Article
The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
16 Jun 2025
Abstract excerpt
Despite conjugate vaccine introduction to prevent invasive pneumococcal disease (IPD), serotype replacement by non-vaccine serotypes is a constant concern. In this study, we elucidate the rise of serotype 8 causing IPD in Spain. We evaluated isolates received during the period 2008–2023 including whole genome sequencing characterization and host-pathogen interaction studies. Serotype 8 has emerged as one of the...
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