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Article

ApaI Polymorphism in the Vitamin D Receptor Gene Decreases the Risk of Perianal Fistulas in Crohn's Disease.

Nutrients - 14 Oct 2024

Gisbert-Ferrándiz Laura, Llau Jorge, Ortiz-Masia Dolores, Cosín-Roger Jesús, Macias-Ceja Dulce Carolina, Hinojosa Joaquín, Calatayud Sara, Barrachina Maria Dolores

Abstract excerpt

BACKGROUND: Vitamin D, through the activation of its receptor (VDR), plays an immunomodulatory role in the gastrointestinal tract. Single-nucleotide polymorphisms (SNPs) in the VDR gene have been associated with Crohn's disease (CD) risk, and patients carrying the TaqI polymorphism in this gene run a higher risk of developing a penetrating behavior. AIMS: We analyzed the association of BsmI, ApaI, TaqI, and FokI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39458479
DOI: 10.3390/nu16203485
PMCID: PMC11510363

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