Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia

15 Mar 2019

Abstract excerpt

Abstract Pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is associated with a high frequency of copy number alterations (CNAs) in IKZF1 , EBF1 , PAX5 , CDKN2A/B , RB1 , BTG1 , ETV6 , and/or the PAR1 region (henceforth: B-cell development genes). We aimed to gain insight in the association between CNAs in these genes, clinical outcome parameters, and cellular drug resistance. 71% of newly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Childhood Cancer Survivors' Quality of Life
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30874617
DOI: 10.1038/s41598-019-41078-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemiaPMID 30874617Read ↗

Gene copy number alteration profile and its clinical correlation in B-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocolsSemantic proximity Read ↗

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.Semantic proximity Read ↗

New biological and genetic classification and therapeutically relevant categories in childhood B-cell precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

The Prognostic Effect of CDKN2A/2B Gene Deletions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM-Based ProtocolsSemantic proximity Read ↗

IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemiaSemantic proximity Read ↗

DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes InvolvedSemantic proximity Read ↗

Prognostic impact of copy number alterations in pediatric B-cell precursor acute lymphoblastic leukemia: A collaborative data from two major oncology centers of North IndiaSemantic proximity Read ↗

Clinical Relevance and Applicability of the 2022 World Health Organization Classification of Childhood B Lymphoblastic Leukemia in the Context of MRD-Directed TherapySemantic proximity Read ↗

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical featuresSemantic proximity Read ↗

IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.