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Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

21 May 2018

Abstract excerpt

Cellular senescence is a form of cell cycle arrest that limits the proliferative potential of cells, including tumour cells. However, inability of immune cells to subsequently eliminate senescent cells from the organism may lead to tissue damage, inflammation, enhanced carcinogenesis and development of age-related diseases. We found that the anticancer agent mitochondria-targeted tamoxifen (MitoTam), unlike...

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PMID: 29786070
DOI: 10.1038/s41418-018-0118-3

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