Article
Hybrid Epithelial-Mesenchymal Phenotypes Are Controlled by Microenvironmental Factors.
Cancer research - 1 Jun 2020
Selvaggio Gianluca, Canato Sara, Pawar Archana, Monteiro Pedro T, Guerreiro Patrícia S, Brás M Manuela, Janody Florence, Chaouiya Claudine
Abstract excerpt
Epithelial-to-mesenchymal transition (EMT) has been associated with cancer cell heterogeneity, plasticity, and metastasis. However, the extrinsic signals supervising these phenotypic transitions remain elusive. To assess how selected microenvironmental signals control cancer-associated phenotypes along the EMT continuum, we defined a logical model of the EMT cellular network that yields qualitative degrees of...
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