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Article

Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017

Choo Hyo-Jung, Kholmukhamedov Andaleb, Zhou ChengZing, Jobe Shawn

Abstract excerpt

OBJECTIVE: Phosphatidylserine exposure mediates platelet procoagulant function and regulates platelet life span. Apoptotic, necrotic, and integrin-mediated mechanisms have been implicated as intracellular determinants of platelet phosphatidylserine exposure. Here, we investigate (1) the role of mitochondrial events in platelet phosphatidylserine exposure initiated by these distinct stimuli and (2) the cellular...

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Identifiers

PMID: 28663253
DOI: 10.1161/ATVBAHA.117.309473
PMCID: PMC5560492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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