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Article

Apoptosis in megakaryocytes and platelets: the life and death of a lineage

19 Dec 2017

Abstract excerpt

Despite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability. Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circulation....

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Identifiers

PMID: 29259001
DOI: 10.1182/blood-2017-11-742684

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