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Article

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo.

Drug design, development and therapy - 1 Jan 2018

Sychev Dmitrij A, Ashraf Ghulam Md, Svistunov Andrey A, Maksimov Maksim L, Tarasov Vadim V, Chubarev Vladimir N, Otdelenov Vitalij A, Denisenko Natal'ja P, Barreto George E, Aliev Gjumrakch

Abstract excerpt

Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. Inhibition and induction of CYP isoenzymes caused by drugs are important and clinically relevant pharmacokinetic mechanisms of drug interaction. Investigation of the activity of CYP isoenzymes by using phenotyping methods...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29780235
DOI: 10.2147/DDDT.S149069
PMCID: PMC5951216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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