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Article

Clinical importance of the cytochromes P450.

Lancet (London, England) - 12 Oct 2002

Nebert Daniel W, Russell David W

Abstract excerpt

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed...

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PMID: 12387968
DOI: 10.1016/S0140-6736(02)11203-7

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