Article
Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis.
Chinese medical journal - 20 Aug 2023
Xu Xia, Lu Haiwen, Li Jianxiong, Duan Jielin, Wang Zhongwei, Yang Jiawei, Gu Shuyi, Luo Rongguang, Liang Shuo, Tang Wei, Zhang Fengying, Hang Jingqing, Ge Juan, Lin Xin, Qu Jieming, Jia Xinming, Xu Jinfu
Abstract excerpt
BACKGROUND: Previous research demonstrated that a homozygous mutation of g.136372044G>A (S12N) in caspase recruitment domain family member 9 ( CARD9 ) is critical for producing Aspergillus fumigatus -induced ( Af -induced) T helper 2 (T H 2)-mediated responses in allergic bronchopulmonary aspergillosis (ABPA). However, it remains unclear whether the CARD9S12N mutation, especially the heterozygous occurrence,...
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