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Article

Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes.

G3 (Bethesda, Md.) - 2 Jul 2018

Hirai Kazuyuki, Wang Zhuo, Miura Kohei, Hayashi Takaaki, Awasaki Takeshi, Wada Moe, Keira Yoko, Ishikawa Hiroyuki O, Sawamura Kyoichi

Abstract excerpt

ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the maternal supply is necessary for embryonic development. Subsequent to fertilization, mitotic progression of the embryos produced by the mutant females is severely...

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Identifiers

PMID: 29773558
DOI: 10.1534/g3.118.200361
PMCID: PMC6027884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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