Article

Mutations that Affect Channel Opening of Innexin Hemichannels in the C. elegans Gonad

2020-11-03

Abstract excerpt

In C. elegans, gap junctions couple cells of the somatic gonad with the germline to support germ cell proliferation and gametogenesis. We previously characterized a strong loss-of-function mutation (T239I) affecting the second extracellular loop (EL2) of the somatic INX-8 hemichannel subunit. These mutant hemichannels form non-functional gap junctions with germline-expressed innexins. Here we describe the characte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0011e4f-dab6-5894-9ade-0803dbc401b1
DOI: 10.20944/preprints202011.0151.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations that Affect Channel Opening of Innexin Hemichannels in the C. elegans GonadDOI 10.20944/preprints202011.0151.v1Read

A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the Caenorhabditis elegans Somatic Gonad.Semantic proximity Read

Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans.Semantic proximity Read

ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.Semantic proximity Read

Functional validation of human SK channels variants causing NEDMAB and Zimmermann-Laband syndrome-3 in <i>C. elegans</i>Semantic proximity Read

Six innexins contribute to electrical coupling of C. elegans body-wall muscle.Semantic proximity Read

The Caenorhabditis elegans innexin INX-3 is localized to gap junctions and is essential for embryonic development.Semantic proximity Read

The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization.Semantic proximity Read

Innexins: members of an evolutionarily conserved family of gap-junction proteins.Semantic proximity Read

Genetic diseases and gene knockouts reveal diverse connexin functions.Semantic proximity Read

<i>Caenorhabditis elegans</i> models for striated muscle disorders caused by missense variants of human <i>LMNA</i>Semantic proximity Read

Genes, gene knockouts, and mutations in the analysis of gap junctions.Semantic proximity Read

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytiaSemantic proximity Read