Article
Thousands of missed genes found in bacterial genomes and their analysis with COMBREX.
Biology direct - 30 Oct 2012
Wood Derrick E, Lin Henry, Levy-Moonshine Ami, Swaminathan Rajiswari, Chang Yi-Chien, Anton Brian P, Osmani Lais, Steffen Martin, Kasif Simon, Salzberg Steven L
Abstract excerpt
BACKGROUND: The dramatic reduction in the cost of sequencing has allowed many researchers to join in the effort of sequencing and annotating prokaryotic genomes. Annotation methods vary considerably and may fail to identify some genes. Here we draw attention to a large number of likely genes missing from annotations using common tools such as Glimmer and BLAST. RESULTS: By analyzing 1,474 prokaryotic genome...
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