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Article

Comprehensive detection of genes causing a phenotype using phenotype sequencing and pathway analysis.

PloS one - 1 Jan 2014

Harper Marc, Gronenberg Luisa, Liao James, Lee Christopher

Abstract excerpt

Discovering all the genetic causes of a phenotype is an important goal in functional genomics. We combine an experimental design for detecting independent genetic causes of a phenotype with a high-throughput sequencing analysis that maximizes sensitivity for comprehensively identifying them. Testing this approach on a set of 24 mutant strains generated for a metabolic phenotype with many known genetic causes, we...

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PMID: 24586303
DOI: 10.1371/journal.pone.0088072
PMCID: PMC3935835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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