Article
Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2018
Hishinuma Eiji, Narita Yoko, Saito Sakae, Maekawa Masamitsu, Akai Fumika, Nakanishi Yuya, Yasuda Jun, Nagasaki Masao, Yamamoto Masayuki, Yamaguchi Hiroaki, Mano Nariyasu, Hirasawa Noriyasu, Hiratsuka Masahiro
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD, EC 1.3.1.2), encoded by the DPYD gene, is the rate-limiting enzyme in the degradation pathway of endogenous pyrimidine and fluoropyrimidine drugs such as 5-fluorouracil (5-FU). DPD catalyzes the reduction of uracil, thymine, and 5-FU. In Caucasians, DPYD mutations, including DPYD*2A, DPYD*13, c.2846A>T, and c.1129-5923C>G/hapB3, are known to contribute to interindividual...
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