Functional characterization of 21 allelic variants of dihydropyrimidinase.

doi:10.1016/j.bcp.2017.06.121

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Article

Functional characterization of 21 allelic variants of dihydropyrimidinase.

Biochemical pharmacology - 1 Nov 2017

Hishinuma Eiji, Akai Fumika, Narita Yoko, Maekawa Masamitsu, Yamaguchi Hiroaki, Mano Nariyasu, Oda Akifumi, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Dihydropyrimidinase (DHP, EC 3.5.2.2), encoded by the gene DPYS, is the second enzyme in the catabolic pathway of pyrimidine and of fluoropyrimidine drugs such as 5-fluorouracil, which are commonly used in anticancer treatment; DHP catalyzes the hydrolytic ring opening of dihydrouracil and dihydro-5-fluorouracil. DPYS mutations are known to contribute to interindividual variations in the toxicity of...

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PMID: 28642038
DOI: 10.1016/j.bcp.2017.06.121

Genes

DPYS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.