Article
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity.
Pharmacogenomics - 1 Sept 2011
Amstutz Ursula, Froehlich Tanja K, Largiadèr Carlo R
Abstract excerpt
The importance of polymorphisms in the dihydropyrimidine dehydrogenase (DPD) gene (DPYD) for the prediction of severe toxicity in 5-fluorouracil (5-FU) based chemotherapy has been controversially debated. As a key enzyme in the catabolism of 5-FU, DPD is the top candidate for pharmacogenetic studies on 5-FU toxicity, since a reduced DPD activity is thought to result in an increased half-life of the drug, and...
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