Article
Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model.
Oxidative medicine and cellular longevity - 1 Jan 2018
Guido Maria C, Debbas Victor, Salemi Vera M, Tavares Elaine R, Meirelles Thayna, Araujo Thaís L S, Nolasco Patricia, Ferreira-Filho Julio C A, Takimura Celso K, Pereira Lygia V, Laurindo Francisco R
Abstract excerpt
Marfan syndrome (MFS) cardiovascular manifestations such as aortic aneurysms and cardiomyopathy carry substantial morbidity/mortality. We investigated the effects of lipoic acid, an antioxidant, on ROS production and aortic remodeling in a MFS mgΔloxPneo mouse model. MFS and WT (wild-type) 1-month-old mice were allocated to 3 groups: untreated, treated with losartan, and treated with lipoic acid. At 6 months old,...
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