Article
Macrophage plasticity, polarization, and function in health and disease.
Journal of cellular physiology - 1 Sept 2018
Shapouri-Moghaddam Abbas, Mohammadian Saeed, Vazini Hossein, Taghadosi Mahdi, Esmaeili Seyed-Alireza, Mardani Fatemeh, Seifi Bita, Mohammadi Asadollah, Afshari Jalil T, Sahebkar Amirhossein
Abstract excerpt
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro-inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th1 cytokines such as IFN-γ, GM-CSF, and produce pro-inflammatory cytokines such as interleukin-1β...
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