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Unbalanced M1/M2 Phenotype of Peripheral Blood Monocytes in Obese Diabetic Patients

29 Dec 2009

Abstract excerpt

The monocyte-macrophage system exists in at least two distinct phenotypes of differentiation: proinflammatory (M1) and anti-inflammatory (M2) (1,2). Macrophages, when infiltrated into obese adipose tissue, exhibit a phenotypic switch from M2 to M1 polarization, thereby contributing to obesity-induced adipose tissue inflammation and insulin resistance (1). Expression of both M1 and M2 markers is detected in...

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PMID: 20040670
DOI: 10.2337/dc09-1315

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