Article
Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.
Gastroenterology - 1 Sept 2007
Volz Tassilo, Lutgehetmann Marc, Wachtler Paul, Jacob Anna, Quaas Alexander, Murray John M, Dandri Maura, Petersen Joerg
Abstract excerpt
BACKGROUND & AIMS: Knowledge of factors regulating transcriptional activity of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) may help in understanding mechanisms of viral decay and how these processes are thwarted in chronically HBV-infected patients. METHODS: Liver biopsies from 119 treatment-naive chronically infected patients (42 HBeAg-positive and 77 HBeAg-negative) were determined for HBV...
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